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December 8, 2025BloodOpen Access

Real-world post-relapse survival outcomes in children with Acute Myeloid Leukemia by race and ethnicity

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Authors

QKQuynh Long KhuongKBKira BonaCECaitlin W. Elgarten

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Overview

Retrospective analysis demonstrates worse survival outcomes in NHB children with acute myeloid leukemia post-relapse, suggesting significant disparities.

Key Points

  • Post-relapse overall survival shows significant disparities, especially increased hazard of death for NHB children.
  • Hispanic patients had comparable outcomes to NHW peers, while NHB children faced a 64% higher risk of death post-relapse.
  • The analysis employed Cox models adjusting for clinical features and treatment history in a real-world cohort.
  • Findings highlight a potential need for tailored therapies addressing the specific challenges faced by NHB children at relapse.

Cite This Study

Khuong et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd7fhttps://doi.org/10.1182/blood-2025-602
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Disparate post-relapse survival outcomes by race/ethnicity for children with B-cell acute lymphoblastic leukemia: An analysis from the recall-1 study2025
  2. 2Racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML)2025
  3. 3Role of race and ethnicity in survival among children/young adults with relapsed ALL: a Children’s Oncology Group report2025 · 2 citations
  4. 4Rethinking disparity in Acute Myeloid Leukemia, a new perspective in the Asian population2025
  5. 5Inferior survival in black AML patients treated with intensive chemotherapy in ECOG-ACRIN clinical trials is independent of cytogenetic profiles2025