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December 8, 2025BloodOpen Access

Racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML)

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Authors

PPPujan PatelJSJinming SongRSRory M. Shallis

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Overview

Retrospective analysis shows Black patients have shorter survival in acute myeloid leukemia, indicating disparities in genomic alterations and treatment outcomes.

Key Points

  • Black patients diagnosed with acute myeloid leukemia exhibited shorter overall survival compared to White and Hispanic cohorts, especially in the intermediate-risk group.
  • Median overall survival was 2.2 years for the entire cohort, with significant variation noted across racial groups during analysis.
  • Observational analysis at Moffitt Cancer Center assessed outcomes in over 620 patients diagnosed with acute myeloid leukemia from 2014 to 2024.
  • Disparities in genomic alterations among racial groups underscore the importance of increased minority representation in clinical trials.

Cite This Study

Patel et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d367https://doi.org/10.1182/blood-2025-4630
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