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December 8, 2025Blood

An analysis of the mutational landscape of Acute Myeloid Leukemia at an urban tertiary care center: A retrospective cohort study

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Authors

SRSyed Shahrukh RizviAWAlexander WillisJLJessie Li

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Overview

Retrospective analysis reveals racial disparities in AML mutations and clinical trial representation.

Key Points

  • The study aims to evaluate mutations in Acute Myeloid Leukemia patients and their association with demographic factors.
  • Retrospective cohort study of 119 AML patients diagnosed from 2020 to 2025
  • Data collected on race, ethnicity, age, gender, and neogenomic test results
  • Utilized Slicer Dicer and Epic Charting Software for data collection
  • Data analyzed using Microsoft Excel and R statistical software.
  • Cohort demographics: 53% White, 34% Black, 9% Asian/Pacific Islander, 4% Other
  • Five most common mutations: TET2, FLT3, DNMT3A, ASXL1, IDH2
  • Notable differences in demographics and genetic findings compared to previous studies
  • Higher frequency of high-risk TP53 mutations in NH Black patients.

Cite This Study

Rizvi et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d2c0https://doi.org/10.1182/blood-2025-7037
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