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December 8, 2025BloodOpen Access

Rapidly progressive acute chest syndrome is associated with complement-mediated cell injury in adults with sickle cell disease

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Authors

JFJ.L. FigueroaRBRobert A. BrodskyMCMichael D. Cole

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Overview

Analysis uncovers complement activation and multiorgan failure in rapidly progressive acute chest syndrome patients with sickle cell disease, implying a need for clinical evaluation of eculizumab.

Key Points

  • Patients with rapidly progressive acute chest syndrome demonstrated elevated complement activation and multiorgan failure in a small cohort, indicating urgent clinical implications.
  • A positive mHam assay was observed in all patients with rapidly progressive acute chest syndrome, compared to none in other groups, showing significant complement-mediated cell injury.
  • This observational analysis indicates a potential link between respiratory failure and complement dysregulation in adults with sickle cell disease during acute crises.
  • These findings highlight the necessity for larger studies to validate results and further explore therapeutic options such as eculizumab for complement modulation.

Cite This Study

Figueroa et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2c2https://doi.org/10.1182/blood-2025-6485
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deep neutrophil phenotyping uncovers complement-mediated neutrophil dysregulation in sickle cell disease2025
  2. 2Complement dysregulation during vaso-occlusive episodes can predict development of acute chest syndrome in pediatric patients with sickle cell disease2025
  3. 3Clinical and laboratory findings in adults with sickle cell disease which increase risk for severe acute chest syndrome2025
  4. 4Revisiting acute chest syndrome (ACS) associated with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE): Insight from a prospective, multicenter Phase-3 randomized controlled trial2025 · 1 citations
  5. 5Acute chest syndrome (ACS) in sickle cell disease (SCD): pathogenesis and pharmacotherapies in early clinical development2025 · 3 citations