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December 8, 2025BloodOpen Access

Sex-based disparities in MPN treatment patterns: A study of 1167 patients from the Quebec MPN registry

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Authors

LBLambert Busque

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Overview

Observational analysis highlights differences in treatment discontinuation and drug exposure in polycythemia vera and myelofibrosis patients, suggesting a need for better-tolerated agents.

Key Points

  • Women account for 55% of patients in this examination of treatment patterns in myeloproliferative neoplasms.
  • Among polycythemia vera patients, ruxolitinib use is notably higher in men (9.2%) compared to women (3.1%).
  • Analysis of the Quebec MPN Registry data reveals significant treatment discontinuation differences driven by intolerance in women versus resistance in men.
  • These findings underscore the importance of sex-specific therapeutic strategies and risk stratifications in managing comorbidities.

Cite This Study

Lambert Busque (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e477https://doi.org/10.1182/blood-2025-723
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Also Consider

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