Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 16, 2025Journal of Clinical MedicineOpen Access

Sex-Associated Differences in Outcomes in Acute Myeloid Leukemia Patients Following Intense Induction Treatment: A Real-World Single Center Analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

XDXenia DarphinJBJanina BlattnerMHMichèle J. HoffmannDüsseldorf University Hospital

Discussion

Loading...

Member takes

Implication

Retrospective analysis reveals sex differences in toxicity and hospitalization for AML patients, suggesting implications for treatment.

Key Points

  • Females experienced significantly higher rates of neutropenic colitis (100% vs. 80%) after the first induction cycle.
  • Males showed faster hematological recovery times post-treatment with neutrophils recovering in 21 days compared to 28 days for females.
  • Hospitalization duration was notably longer for females at 26 days versus 24 days for males, indicating potential treatment disparities.
  • Overall survival was not significantly different by sex, but younger patients (<60 years) and those receiving two cycles had improved outcomes.

Cite This Study

Darphin et al. (2025) studied this question.

synapsesocial.com/papers/68d4262e713b0b5dfea6bec7https://doi.org/10.3390/jcm14186457
View Full Paper
Ask AI
Bookmark
Share