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December 8, 2025BloodOpen Access

Characterizing differences in CAR-T cell therapy outcomes based on sex in patients with large B-cell lymphoma

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Authors

MAMuhammad Bilal Abid

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Overview

Retrospective analysis finds female patients exhibit improved progression free survival in CAR-T therapy, suggesting critical immune response differences.

Key Points

  • Progression free survival significantly favored females over males, highlighting immune response variations.
  • Cumulative incidence of relapse was lower in females at 31.4%, compared to 47.1% in males after 12 months.
  • Multivariate analysis confirmed male patients faced increased relapse risk and inferior progression free survival.
  • Findings indicate the need to consider sex and hormonal factors in CAR-T therapy decision-making.

Cite This Study

Muhammad Bilal Abid (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d5a2https://doi.org/10.1182/blood-2025-1948
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