December 8, 2025Blood

Beyond the genome: An integrated multi-omics approach to uncover histone ptm-driven metabolic and proteomic regulation in AML

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VVVanessa VermeirssenUniversity College Ghent

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Implication

This analysis identifies histone post-translational modifications and metabolites in acute myeloid leukemia, suggesting new metabolic regulation mechanisms.

Key Points

Metabolic regulation is linked to histone post-translational modifications in acute myeloid leukemia.
Machine-learning based multi-omics analysis uncovered 99 protein co-expression modules related to the epigenome.
Mass-spectrometry integrated the epigenome, proteome, and metabolome from 18 genetically distinct AML cell lines.
Findings highlight the complexity of AML pathobiology, indicating potential for further research on its molecular mechanisms.

Cite This Study

Vanessa Vermeirssen (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e451 https://doi.org/10.1182/blood-2025-1448

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Implication

This analysis identifies histone post-translational modifications and metabolites in acute myeloid leukemia, suggesting new metabolic regulation mechanisms.

Beyond the genome: An integrated multi-omics approach to uncover histone ptm-driven metabolic and proteomic regulation in AML

Discussion

Member takes

Implication

Key Points

Cite This Study

Beyond the genome: An integrated multi-omics approach to uncover histone ptm-driven metabolic and proteomic regulation in AML

Discussion

Member takes

Implication

Key Points

Cite This Study

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