What type of study is this?

This is a Cohort Study study (also classified as: Human Clinical Trial, Phase 1, Pre-Registered Trial).

December 8, 2025Blood

Total marrow irradiation-based, intensified reduced-intensity conditioning regimen for hematopoietic cell transplantation in patients aged 60 years or older: A prospective study

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Overall survival rate was 45% at 24 months for patients aged 60 years and older with acute myeloid leukemia.
Neutrophil engraftment observed in 93% of patients with median time of 17 days, highlighting effectiveness of the regimen.
Hematopoietic cell transplantation involved total marrow irradiation with busulfan and fludarabine for conditioning.
Supports the development of intensified conditioning regimens for fragile elderly populations in future studies.

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Implication

Prospective study shows 45% overall survival in patients aged 60+ after intensified conditioning with tacrolimus and mycophenolate, indicating effective treatment potential.

Cite This Study

Kerbauy et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3e3 https://doi.org/10.1182/blood-2025-2439

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Implication

Prospective study shows 45% overall survival in patients aged 60+ after intensified conditioning with tacrolimus and mycophenolate, indicating effective treatment potential.

Total marrow irradiation-based, intensified reduced-intensity conditioning regimen for hematopoietic cell transplantation in patients aged 60 years or older: A prospective study

Key Points

Discussion

Implication

Cite This Study

Total marrow irradiation-based, intensified reduced-intensity conditioning regimen for hematopoietic cell transplantation in patients aged 60 years or older: A prospective study

Key Points

Discussion

Implication

Cite This Study

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