Total marrow irradiation-based, intensified reduced-intensity conditioning regimen for haploidentical hematopoietic cell transplantation with posttransplant cyclophosphamide: A prospective study
To evaluate the efficacy of a total marrow irradiation-based reduced-intensity conditioning regimen in haploidentical hematopoietic cell transplantation.
Prospective single-center study from 2018 to 2025
Patients received haploidentical transplantation with a specific conditioning regimen
Follow-up included assessment of engraftment and survival rates.
95% neutrophil engraftment was achieved among evaluable patients
18-month overall survival was 59% and progression-free survival was 53%
Rates of acute and chronic graft-versus-host disease were documented.