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December 8, 2025BloodOpen Access

Total marrow irradiation based conditioning for allogeneic hematopoietic stem cell transplantation in elderly or frail patients with hematological malignancies: A single center analysis

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Authors

LWLing Wang

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Overview

Analysis reveals TMI conditioning improves engraftment with lower relapse in elderly patients with hematological malignancies, indicating reduced toxicity.

Key Points

  • Overall survival reached 79.2% at one year for elderly patients, suggesting potential benefits of total marrow irradiation.
  • Patients with acute myeloid leukemia showed promising outcomes with median days to neutrophil recovery of 14 days post-TMI conditioning.
  • The study included patients aged 60 and older with performance status ≥ 3, indicating a high-risk cohort for stem cell transplantation.
  • Graft-versus-host disease prophylaxis after transplantation was implemented effectively, showing a 25% incidence of acute GVHD.

Cite This Study

Ling Wang (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1d6https://doi.org/10.1182/blood-2025-2444
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