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December 8, 2025Blood

High-throughput single-cell methylation resolves epigenetic states in hematopoietic differentiation and age-related clonal expansions

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Authors

CVCarolina Varona-ArguellesPGPeter van Galen

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Overview

DREAM-seq demonstrates enhanced DNA methylation profiling in hematopoietic differentiation, highlighting implications for malignancy.

Key Points

  • Methylation profiling identified key regulatory states in hematopoietic differentiation and malignancy.
  • The analysis captured over 5,000 single-cell methylomes, improving resolution and identification of cell types.
  • This high-throughput technology, based on droplet microfluidics, enhances understanding of aged hematopoietic populations.
  • Findings suggest that DNA methylation plays critical roles in lineage specification and may influence malignancy risk.

Cite This Study

Varona-Arguelles et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e366https://doi.org/10.1182/blood-2025-977
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Also Consider

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  1. 1Detecting lineage-specific regulatory activity and stemness retention in single-cell multiomics of human hematopoiesis2025
  2. 2DNMT1-mediated epigenetic regulation of heterochromatin in cellular aging2025
  3. 3Single-cell genotyping and methylome sequencing (scGEM-seq) resolves cell-states and clonal hierarchies in leukemia2025
  4. 4Hypermethylation of the ribosomal DNA coding sequence and disordered transcription factor binding as hallmarks of acute myeloid leukemia2025
  5. 5Trimodal single-cell profiling reveals principles of cell fate acquisition in human erythropoiesis.2025 · 1 citations