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December 8, 2025BloodOpen Access

Detecting lineage-specific regulatory activity and stemness retention in single-cell multiomics of human hematopoiesis

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Authors

CJC. Diana JordanDODominik J. OttoMSManu Setty

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Overview

Observational analysis reveals key regulatory patterns in hematopoiesis, suggesting epigenetic alterations in HSPCs drive lineage-specific outcomes.

Key Points

  • Co-occurring changes in transcription and histone modifications signify lineage-specific activity in B lymphopoiesis.
  • Key genes like PAX5 show unique regulation during hematopoiesis, particularly in the B cell lineage.
  • Single-cell multiomics approaches integrate various profiles to elucidate chromatin accessibility and epigenetic marks.
  • Further exploration of regulatory dynamics may illuminate disruptions in HSPC fate in hematologic malignancies.

Cite This Study

Jordan et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6d7https://doi.org/10.1182/blood-2025-6119
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  5. 5Identification of two distinct human hematopoietic stem cell subsets and their age-dependent dynamics by single-cell multi-omics2025 · 1 citations