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December 8, 2025Blood

Trimodal single-cell profiling reveals principles of cell fate acquisition in human erythropoiesis.

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Authors

STSteven TurJRJeffrey A. Ranish

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Overview

Single-cell profiling demonstrates cell fate acquisition in human erythropoiesis, suggesting chromatin accessibility and transcription factors play key roles.

Key Points

  • Transcription factors were shown to drive initial cell fate changes in erythropoiesis, with chromatin accessibility later becoming dominant.
  • Single-cell profiling was employed to measure gene expression, chromatin accessibility, and surface proteins in human hematopoiesis.
  • Dynamic gene regulatory networks were identified, highlighting the interplay of transcription factors and chromatin accessibility throughout cell differentiation.
  • This work establishes a new framework for understanding how lineage commitment occurs in hematopoiesis, emphasizing the non-synchronous nature of stemness loss and lineage acquisition.

Cite This Study

Tur et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e361https://doi.org/10.1182/blood-2025-967
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