September 20, 2025Open Access

Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human Hematopoiesis

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Dynamic gene regulatory networks reveal the uncoupling of stemness loss and lineage identity in hematopoiesis, suggesting new mechanisms.

Hematopoiesis involves a gradual decline in stemness and stepwise acquisition of lineage identity, revealing distinct regulatory dynamics.
The study identifies a high-resolution framework using trimodal single-cell analysis to uncover molecular programs in hematopoietic fate decisions.
Enhancer-based gene regulatory networks demonstrate that stemness loss occurs prior to chromatin closure, facilitating lineage identity transitions.
Findings support both continuous and discrete models of hematopoiesis, indicating the utility of dynamic eGRNs in defining cell regulatory states.

Palii et al. (2025) studied this question.

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September 20, 2025Open Access

View Full Paper

Ask AI

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Authors

Dynamic gene regulatory networks reveal the uncoupling of stemness loss and lineage identity in hematopoiesis, suggesting new mechanisms.

Hematopoiesis involves a gradual decline in stemness and stepwise acquisition of lineage identity, revealing distinct regulatory dynamics.
The study identifies a high-resolution framework using trimodal single-cell analysis to uncover molecular programs in hematopoietic fate decisions.
Enhancer-based gene regulatory networks demonstrate that stemness loss occurs prior to chromatin closure, facilitating lineage identity transitions.
Findings support both continuous and discrete models of hematopoiesis, indicating the utility of dynamic eGRNs in defining cell regulatory states.

Palii et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark