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September 22, 2025Experimental HematologyOpen Access

Three-dimensional Genome Reorganization in Hematopoietic Stem Cells

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Authors

ANAkihiro NakajimaKKKeita KiritoMNMio Nakanishi

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Overview

This review reveals how 3D genome organization influences hematopoietic stem cells, suggesting implications for disorders.

Key Points

  • 3D genome reorganization profoundly affects hematopoietic stem cell (HSC) functions and their adaptability.
  • Advancements in chromatin capture methods have illuminated the dynamic nature of HSC genome architecture.
  • Key transcription factors and epigenetic modifiers shape the HSC genome, impacting differentiation and aging.
  • Alterations in 3D genome organization may lead to dysfunction, contributing to various hematological disorders.

Cite This Study

Nakajima et al. (2025) studied this question.

synapsesocial.com/papers/68d43c95713b0b5dfea7ca3bhttps://doi.org/10.1016/j.exphem.2025.105249
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unlocking hematopoietic stem cell potential: integrative computational approaches for genomic and transcriptomic analysis2025 · 4 citations
  2. 23D Genome Architecture in Stem Cell Lineage Commitment: from Structural Organization to Precision Regulation2025
  3. 3Regulation of Hematopoietic Stem Cell Dormancy and Quiescence: Insights into Regeneration and Disease2025 · 8 citations
  4. 4Trimodal single-cell profiling reveals principles of cell fate acquisition in human erythropoiesis.2025 · 1 citations
  5. 5Detecting lineage-specific regulatory activity and stemness retention in single-cell multiomics of human hematopoiesis2025