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December 8, 2025BloodOpen Access

Outcomes of long-term anticoagulation use in patients hospitalized with sickle cell vaso-occlusive crisis: A weighted analysis of the national inpatient sample (2016–2022)

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Authors

AYAkeem YusufAKAbdulrahman Al Kotob

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Overview

Weighted analysis shows elevated risks of thrombotic events in hospitalized adults with sickle cell disease, highlighting complex anticoagulation outcomes.

Key Points

  • Inpatient mortality remained low overall at 0.5%, with no significant difference between anticoagulated and non-anticoagulated groups.
  • Patients on anticoagulation had a longer mean length of stay of 6.34 days compared to 5.41 days, with p<0.0001 significance.
  • Anticoagulated patients had higher incidences of pulmonary embolism at 3.6% and deep vein thrombosis at 1%, both significant at p<0.0001.
  • Results suggest anticoagulation may lead to higher rates of select bleeding events like epistaxis and intracebral hemorrhage.

Cite This Study

Yusuf et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2d9https://doi.org/10.1182/blood-2025-6500
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Venous thromboembolism in adults with sickle cell disease: A national inpatient sample analysis (2016–2020)2025
  2. 2Influence of cardiovascular co-morbidities on the in-hospital mortality among patients with sickle cell crisis2025
  3. 3Pilot study on thrombosis risk factors in sickle cell anemia2025
  4. 4Disparities in venous thromboembolism management in patients with sickle cell disease: A nationwide inpatient sample study2025
  5. 5Long‐Term Anticoagulation and Outcomes of Head and Neck Cancer: Analysis of the US Nationwide Inpatient Sample2025