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December 8, 2025BloodOpen Access

Complement dysregulation during vaso-occlusive episodes can predict development of acute chest syndrome in pediatric patients with sickle cell disease

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Authors

AWAdrianna WestbrookJYJustin YooJJJayre Jones

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Overview

Observational analysis identifies hemolysis biomarkers predicting acute chest syndrome in pediatric sickle cell disease patients, suggesting improved risk assessment is necessary.

Key Points

  • Increased levels of biomarkers such as hemoglobin F and white blood cells predict acute chest syndrome risk in sickle cell disease patients.
  • A logistic regression analysis indicated hemolysis and white blood cell levels can act as significant predictors for acute chest syndrome.
  • The area under the curve metrics demonstrated strong performance for biomarkers in discriminating acute chest syndrome outcomes.
  • Elevated biomarker levels highlight the urgent need for early intervention strategies to prevent acute chest syndrome in high-risk patients.

Cite This Study

Westbrook et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e493https://doi.org/10.1182/blood-2025-1167
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