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December 8, 2025BloodOpen Access

R2* MRI in evaluation of hepatic iron overload and its correlation with serum ferritin in transfusion-dependent beta-thalassemia

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Authors

SMSudipta Mohakud

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Overview

Observational analysis assessed liver iron concentration using non-invasive R2* MRI in transfusion-dependent thalassemia patients, suggesting improved management strategies.

Key Points

  • Liver iron concentration from R2* MRI was critically measured, indicating potential inaccuracies in ferritin levels.
  • The study's median R2* value was 549.6 Hz, with significant iron overload found in 82% of patients.
  • Prospective observational study involved blood tests for genetic mutations and liver MRI scans at AIIMS Bhubaneswar.
  • These findings imply that a non-invasive approach may enhance the reliability of monitoring iron levels.

Cite This Study

Sudipta Mohakud (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2bfhttps://doi.org/10.1182/blood-2025-6478
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Also Consider

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  1. 1An echocardiography and ferritin-based screening model to optimise cardiac T2* MRI use for detecting myocardial iron overload in transfusion-dependent thalassemia patients2025
  2. 2EVALUATION OF SERUM IRON PROFILE IN BETA THALASSEMIA PATIENTS2025 · 1 citations
  3. 3Biomarkers of ineffective erythropoiesis in patients with transfusion- dependent thalassemia2025
  4. 4Regional brain iron deposition and functional alterations in thalassemia: a multimodal human study with murine validation2026
  5. 5Multimodal evaluation of brain injury and cerebral iron deposition in thalassemia patients: A combined human-imaging and murine model study2025