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December 8, 2025BloodOpen Access

Multimodal evaluation of brain injury and cerebral iron deposition in thalassemia patients: A combined human-imaging and murine model study

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Observational analysis shows cognitive impairment in thalassemia patients, indicating significant brain injury linked to iron deposition.

Cognitive impairment was found in thalassemia patients, demonstrating consistent deficits across attention and memory domains.
Resting-state functional magnetic resonance imaging revealed significant neural activity alterations in thalassemia patients vs healthy controls.
Quantitative susceptibility mapping indicated elevated brain iron levels in specific regions among thalassemia patients, correlating with cognitive scores.
These findings highlight the importance of using multimodal evaluations to identify neurological complications associated with thalassemia.

Shao et al. (2025) studied this question.

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