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December 8, 2025Blood

An echocardiography and ferritin-based screening model to optimise cardiac T2* MRI use for detecting myocardial iron overload in transfusion-dependent thalassemia patients

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Authors

RSRudra Narayan SwainAGAnkur GuptaAJAditya Jandial

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Overview

Observational analysis identifies iron overload in thalassemia patients using echocardiography and ferritin, suggesting a practical screening model.

Key Points

  • Cardiac risk assessment found 19% of thalassemia patients had iron overload, clearly affecting heart function.
  • Iron overload was linked to significant changes in echocardiographic measures like the right ventricular basal diameter.
  • The approach combined echocardiographic analysis and ferritin levels, achieving a high sensitivity of 92% and specificity of 80%.
  • This study supports the use of basic echocardiographic measures where MRI is inaccessible, indicating broader testing opportunities.

Cite This Study

Swain et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dcaehttps://doi.org/10.1182/blood-2025-943
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1R2* MRI in evaluation of hepatic iron overload and its correlation with serum ferritin in transfusion-dependent beta-thalassemia2025
  2. 2Assessment of Myocardial Iron Overload and Strain Abnormalities in Pediatric β-Thalassemia Using Multiparametric CMR2026
  3. 3Comparative assessments of myocardial iron load in thalassemia patients between dark blood and bright blood MRI T2* techniques2025 · 2 citations
  4. 4Performance and Correlations of Myocardial Contraction Fraction Derived From <scp>MRI</scp> in Transfusion‐Dependent Thalassemia Patients2025 · 2 citations
  5. 5The Association between β-Thalassemia Major (β-TM) and Cardiac Complications: Recent Insights.2025