December 8, 2025Blood

Dynamic roles of hematopoietic notch signaling in extramedullary hematopoiesis

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Authors

KPKostandin V. PajciniUniversity of Illinois Chicago NPNa Yoon PaikUniversity of Illinois Chicago TBThilinie BandaraUniversity of Illinois Chicago

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Implication

Findings show notch signaling regulates functional hematopoietic stem cells in extramedullary hematopoiesis, suggesting implications for bone marrow adaptability.

Key Points

Long-term functional hematopoietic stem cells were identified in the adult liver, supporting extramedullary hematopoiesis.
Transgenic mice models helped demonstrate the essential role of notch signaling in reconstituting irradiated recipients effectively.
Analysis utilized advanced modeling platforms to study interactions between hematopoietic stem cells and their niche.
Findings emphasize the critical role of Jag1 from hematopoietic origin in supporting the stem cell functionality in extramedullary sites.

Cite This Study

Pajcini et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e224 https://doi.org/10.1182/blood-2025-4927

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Implication

Findings show notch signaling regulates functional hematopoietic stem cells in extramedullary hematopoiesis, suggesting implications for bone marrow adaptability.

Dynamic roles of hematopoietic notch signaling in extramedullary hematopoiesis

Discussion

Member takes

Implication

Key Points

Cite This Study

Dynamic roles of hematopoietic notch signaling in extramedullary hematopoiesis

Discussion

Member takes

Implication

Key Points

Cite This Study

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