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This research investigates the distinct functions of fetal hematopoietic stem and progenitor cells in immune system formation.

December 8, 2025BloodOpen Access

Distinct roles of fetal hematopoietic stem and progenitor cells in building the immune system

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Lineage-tracing reveals hematopoietic stem cells contribute minimally pre-birth, implicating eMPPs in fetal immune system development.

This research investigates the distinct functions of fetal hematopoietic stem and progenitor cells in immune system formation.
Used lineage-tracing models to elucidate roles of embryonic multipotent progenitors and hematopoietic stem cells.
Examined contributions of these cells in fetal liver and their impact on postnatal immunity.
Embryonic multipotent progenitors primarily drive hematopoiesis during late gestation.
Hematopoietic stem cells showed minimal contribution to mature blood cells before birth.
Identification of distinct roles supports a revised model of fetal hematopoiesis.

Hatano et al. (2025) studied this question.

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