What type of study is this?

This is a In Vitro Study study.

December 8, 2025Blood

Jagged-1+ damage-resistant myeloid progenitors initiate the recovery of the bone marrow endothelial-niche

View Full Paper

Ask AI

Bookmark

Authors

Transgenic deletion of Jagged-1 reduces HSC recovery in bone marrow, suggesting Notch signaling is crucial for endothelial repair and viability.

Notch signaling plays a critical role in promoting hematopoietic stem cell recovery following myeloablation.
Irradiation compromises endothelial cell viability, leading to poor hematopoietic outcomes if Jag1 is absent.
Single-cell RNA sequencing identifies unique myeloid-derived progenitor populations that aid in endothelial recovery after damage.
Utilizing a cell-free method with non-fusogenic nanoparticles enhances endothelial viability and recovery, emphasizing potential therapeutic avenues.

Neethling et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

Transgenic deletion of Jagged-1 reduces HSC recovery in bone marrow, suggesting Notch signaling is crucial for endothelial repair and viability.