October 12, 2025Open Access

Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow

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Authors

JFJingxin FengNational Institutes of Health MYMeiting YangNational Institutes of Health LLLili LiNational Cancer Institute

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Implication

In vivo genetic lineage tracing reveals hemogenic endothelial cells generating hematopoietic cells in adult mice, suggesting potential for sustained hematopoiesis.

Key Points

Adult hemogenic endothelial cells generate hematopoietic stem and progenitor cells, essential for blood cell production.
Using single-cell RNA sequencing, a small population of Cdh5/VE-Cadherin+ endothelial cells was identified in bone marrow.
These hemogenic endothelial cells can produce functional mature blood cells, contributing to inflammatory responses.
The study highlights the potential of adult endothelial cells in sustaining hematopoiesis via lineage tracing methods.

Cite This Study

Feng et al. (2025) studied this question.

synapsesocial.com/papers/68ebffcfdef9fcb308ff2679 https://doi.org/10.1101/2025.10.09.681472

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Implication

In vivo genetic lineage tracing reveals hemogenic endothelial cells generating hematopoietic cells in adult mice, suggesting potential for sustained hematopoiesis.

Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow

Discussion

Member takes

Implication

Key Points

Cite This Study

Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow

Discussion

Member takes

Implication

Key Points

Cite This Study

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