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December 8, 2025BloodOpen Access

Normal B Cells in MBL follow divergent maturation pathways that correlate with the IGHV mutation status of the pre-leukemic clone

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Authors

XYXiao‐Jie YanANAnita NgLSLadys Sarmiento

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Overview

Transcriptomic analysis reveals distinct B-cell maturation in MBL with implications for inflammation and anti-B-cell responses.

Key Points

  • Divergent maturation pathways of normal B cells were observed between high-count and low-count MBL, indicating distinct transcriptomic landscapes.
  • Analysis revealed a significant increase in cytokine storm pathways in unmutated high-count MBL versus healthy donors.
  • Observational analysis using transcriptomes and flow cytometry showed variation in B-cell subsets across MBL states and healthy controls.
  • Findings support the idea that antigenic challenges influence B-cell development paths based on IGHV mutation status and disease progression.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1bahttps://doi.org/10.1182/blood-2025-3910
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