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December 8, 2025Blood

Stepwise engineering of human germinal center B cells to model dark zone high-grade B cell lymphoma driven by sequential BCL2 and MYC deregulation

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Authors

EMElena MorlacchiGCGiada CicioLLLuisa Lorenzi

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Overview

This research shows tumor formation linked to BCL2 and FOXO1 in human B cells, suggesting new modeling strategies for lymphoma.

Key Points

  • Tumor formation occurred in engineered B cells through BCL2 and FOXO1 activation, highlighting progression in B-cell lymphoma.
  • Engineered cells displayed a specific immunophenotype resembling aggressive lymphoma diseases.
  • Observed transformation utilized a retroviral transduction system to alter primary human GC B cells.
  • Findings support exploring treatments for high-grade B-cell lymphomas with BCL2 and TP53 implications.

Cite This Study

Morlacchi et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db1ahttps://doi.org/10.1182/blood-2025-5339
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RAG1/2 expression in follicular lymphoma marks candidate precursor cells of high-grade B cell lymphoma with MYC and BCL2 rearrangements2025
  2. 2Clinical outcomes, patterns of relapse and molecular landscape of advanced stage High Grade B-cell Lymphoma2026
  3. 3Multimodal profiling identifies CD4+CXCR5+PD-1– Tfh cells as prognostic and predictive biomarkers in diffuse large B-cell lymphoma2025
  4. 4EZH2 oncogenic mutation disrupts germinal center B cell dynamics and promotes early lymphomagenic behaviors2025
  5. 5Linking immunodeficiency with lymphomagenesis: suboptimal T follicular subsets can drive DLBCL transformation 47612025