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December 8, 2025BloodOpen Access

Acquisition of CLL-like epigenetic and transcriptomic states in low-count MBL

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Authors

SFStacey M. FernandesANAdi NaglerDDDavid M. Dorfman

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Overview

Observational analysis found altered gene expression in low-count monoclonal B cell lymphocytosis, indicating precursor states for chronic lymphocytic leukemia.

Key Points

  • CLL-like gene expression changes are evident in low-count MBL, indicating early alterations.
  • Single cell analysis examined 34 peripheral blood samples across various B cell states.
  • Differential chromatin accessibility revealed significant transcription factor activity in CLL progression.
  • Clonal stability observed in MBL/CLL suggests potential for early molecular intervention.

Cite This Study

Fernandes et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d834https://doi.org/10.1182/blood-2025-3876
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Also Consider

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  1. 1Normal B Cells in MBL follow divergent maturation pathways that correlate with the IGHV mutation status of the pre-leukemic clone2025 · 1 citations
  2. 2Single-cell chromatin profiling reveals early epigenetic reprogramming, subtype-specific regulatory networks, and JAK/STAT–IRF vulnerabilities in high-risk chronic myeloid leukemia2025
  3. 3Multi-proteomic analyses provide evidence for origin of a co-existing serum monoclonal gammopathy in CLL/MBL2025
  4. 4Role of the immune microenvironment in the clonal evolution of chronic lymphocytic leukemia2025
  5. 5Exploring molecular heterogeneity and clonal evolution in chronic myelomonocytic leukemia via single-cell transcriptome sequencing2025