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December 8, 2025BloodOpen Access

Sickle cell disease is associated with early-onset clonal hematopoiesis involving DNA damage response pathway mutations

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Authors

CFCourtney D. FitzhughSPSam PollockMRMicah Rickles-Young

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Overview

Multinational analysis reveals increased prevalence of clonal hematopoiesis in sickle cell disease, suggesting risks for leukemia.

Key Points

  • Clonal hematopoiesis is significantly more prevalent in sickle cell disease compared to controls.
  • Among individuals aged 0-19 years, CH prevalence was 10.6% in SCD against 3.5% in non-SCD.
  • Analysis was performed using archival blood DNA from 7,283 subjects across 17 cohorts.
  • The study highlights the specific association of sickle cell disease with increased DNA damage response mutations.

Cite This Study

Fitzhugh et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e184https://doi.org/10.1182/blood-2025-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Screening for clonal hematopoiesis in patients with β-hemoglobinopathies who are candidates to transplant approaches2025 · 1 citations
  2. 2Intermediate and high-risk clonal hematopoiesis in germline predisposition families2025
  3. 3Disproportionate risk of hematologic malignancies in sickle cell disease (SCD) across age strata: A multicenter matched cohort analysis2025
  4. 4Replicative stress-induced aging of hematopoietic stem progenitor cells increases oncogenic mutation burden and incidence of myelodysplasia in sickle cell disease mice2025
  5. 5Clonal hematopoiesis drives T cell dysregulation and immune remodeling revealed by GWAS-based mendelian randomization and single-cell transcriptomics2025