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December 8, 2025BloodOpen Access

Disproportionate risk of hematologic malignancies in sickle cell disease (SCD) across age strata: A multicenter matched cohort analysis

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NCNoemy Coreas

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Overview

Multicenter cohort analysis indicates significant age-related variations in hematologic malignancy risk in sickle cell disease.

Key Points

  • Cumulative incidence of hematologic malignancies was significantly different across all age strata in sickle cell disease.
  • The relative risk of being diagnosed with leukemia peaked at 5.29 in individuals aged 30 to 50 years.
  • A propensity score-matched cohort analysis utilized real-world data from a multicenter electronic health records database.
  • These findings highlight the need for tailored surveillance strategies for hematologic malignancies in patients with sickle cell disease.

Cite This Study

Noemy Coreas (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5e6https://doi.org/10.1182/blood-2025-41
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