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December 8, 2025BloodOpen Access

CⅡTA-mediated up-regulation of MHC reverses immune evasion of leukemia stem cells in refractory/relapsed AML

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Authors

YSYuping SiBDBinbin Dai

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Overview

Enforced MHC expression improves cytotoxicity against leukemia stem cells, suggesting new therapy in AML.

Key Points

  • Tumor-cell apoptosis increased with CⅡTA-mediated MHC expression in leukemia stem cells.
  • In vitro assays showed enhanced cytotoxicity and cytokine production in CⅡTA+ LSCs.
  • Study utilized humanized mice and doxorubicin treatment to evaluate therapeutic impact.
  • Findings support further exploration of immunotherapy for chemoresistant acute myeloid leukemia.

Cite This Study

Si et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dcedhttps://doi.org/10.1182/blood-2025-1509
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