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December 8, 2025BloodOpen Access

Venous thromboembolism and bleeding rates in pregnant and postpartum patients with sickle cell disease

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Authors

SASharl AzarEKElizabeth S. KlingsDSDeborah Siegal

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Overview

Retrospective cohort observed VTE incidence of 17% in pregnant patients with sickle cell disease, indicating high bleeding risk.

Key Points

  • VTE occurred in 17% of pregnancies, substantially above baseline rates in the general population.
  • Thromboembolic events included 90% pulmonary embolism diagnoses, many occurring postpartum.
  • Pregnant patients rarely received anticoagulant prophylaxis, primarily prescribed in those with a history of VTE.
  • Routine thromboprophylaxis usage is complex in pregnant and postpartum patients with sickle cell disease.

Cite This Study

Azar et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d98ehttps://doi.org/10.1182/blood-2025-2947
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcomes associated with mitigating venous thromboembolism risk in pregnant patients with sickle cell disease2025
  2. 2Increased risk of venous thromboembolism and hypertensive disorders during pregnancy in sickle cell disease patients: A meta-analysis focused on actionable outcomes2025
  3. 3Pregnancy related complications and placenta pathology in pregnant women with sickle cell disease2025
  4. 4High rates of severe maternal morbidity and preterm birth among pregnant individuals with sickle cell disease, a nationwide study from 2020-20242025
  5. 5The score settles it? maybe not: Navigating postpartum VTE prophylaxis2025