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December 8, 2025Blood

Trends and predictors of inpatient mortality in patients with aplastic anemia: A 7-year national inpatient sample analysis

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Authors

MUMuhammad UsmanSRSaboor RandhawaFAFaizan Ahmed

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Overview

Retrospective analysis of inpatient mortality trends in aplastic anemia, indicating older age and comorbidity increase risk.

Key Points

  • In-hospital mortality increased significantly among aplastic anemia patients, driven by comorbidity burden.
  • Crude mortality rates for aplastic anemia rose from 5.7% in 2016 to 8.3% in 2021 before declining to 6.8%.
  • Retrospective cohort analysis across National Inpatient Sample data revealed predictors like age and length of stay for mortality.
  • Highlights the need for improved early risk stratification and management strategies for aplastic anemia patients.

Cite This Study

Usman et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236e061https://doi.org/10.1182/blood-2025-6724
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aplastic anemia in patients admitted to the hospital: Clinical characteristics, risk stratification, and outcomes from a large inpatient care database2025
  2. 2Mortality patterns due to aplastic anemia in the United States: A retrospective analysis from 1999 to 20232025
  3. 3Temporal trends in aplastic anemia mortality across u.S. regions (1999–2020)2025
  4. 4A dangerous convergence: Long-term mortality trends in aplastic anemia and sepsis (1999-2023)2025
  5. 5Aplastic anemia mortality in the United States (1999–2023): Trends, disparities, and public health implications2025