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December 8, 2025BloodOpen Access

A dangerous convergence: Long-term mortality trends in aplastic anemia and sepsis (1999-2023)

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Authors

NZNafila ZeeshanSGSwapna GangasaniSMS Mayet

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Overview

Analysis shows rising mortality trends in aplastic anemia and sepsis, indicating significant racial disparities and geographic inequities.

Key Points

  • This research examines 25-year mortality trends in aplastic anemia and sepsis in the U.S.
  • Retrospective analysis of CDC WONDER database from 1999 to 2023
  • Calculated age-adjusted mortality rates per 100,000 persons
  • Assessed trends using Average Annual Percentage Change and Annual Percent Change
  • 140,846 AA-related deaths recorded from 1999 to 2023
  • National age-adjusted mortality rate increased from 2.23 in 1999 to 3.33 in 2023
  • Significant increase in mortality observed post-2018, especially among African Americans and older adults

Cite This Study

Zeeshan et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d18chttps://doi.org/10.1182/blood-2025-6453
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rising sepsis-related mortality in aplastic anemia: A u.S. population-based analysis of temporal trends, disparities, and forecasts through 20302025
  2. 2Mortality patterns due to aplastic anemia in the United States: A retrospective analysis from 1999 to 20232025
  3. 3Aplastic anemia mortality in the United States (1999–2023): Trends, disparities, and public health implications2025
  4. 4Temporal trends in aplastic anemia mortality across u.S. regions (1999–2020)2025
  5. 5Trends and disparities in mortality among patients with anemia and sepsis in the United States from 1999 to 2023: A CDC wonder database analysis2025