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December 8, 2025BloodOpen Access

High rates of severe maternal morbidity and preterm birth among pregnant individuals with sickle cell disease, a nationwide study from 2020-2024

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KDKevin Dysart

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Overview

Nationwide study shows severe maternal morbidity rate of 25% in pregnant individuals with sickle cell disease, indicating significant perinatal outcomes.

Key Points

  • The incidence of severe maternal morbidity among pregnant individuals with sickle cell disease reached 25%, emphasizing a critical health risk.
  • Adjusted odds ratios reveal that patients with sickle cell disease have 8.67 times higher risk of severe maternal morbidity compared to those without.
  • A retrospective cohort study utilized a large electronic health record database from over 1,700 hospitals, analyzing delivery outcomes from 2020-2024.
  • These findings highlight the urgent need for strategies to improve maternal outcomes among high-risk populations, particularly those with sickle cell disease.

Cite This Study

Kevin Dysart (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfc2https://doi.org/10.1182/blood-2025-177
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pregnancy outcomes among women with sickle cell disease: A propensity score-matched analysis approach using the national inpatient sample (2017-2022)2025
  2. 2Increased risk of venous thromboembolism and hypertensive disorders during pregnancy in sickle cell disease patients: A meta-analysis focused on actionable outcomes2025
  3. 3Cardiopulmonary complications during pregnancy as a risk factor for cesarean delivery in a two center, sickle cell disease pregnancy cohort2025
  4. 4Pregnancy related complications and placenta pathology in pregnant women with sickle cell disease2025
  5. 5Venous thromboembolism and bleeding rates in pregnant and postpartum patients with sickle cell disease2025