Increased risk of venous thromboembolism and hypertensive disorders during pregnancy in sickle cell disease patients: A meta-analysis focused on actionable outcomes
Meta-analysis reveals significant risk of venous thromboembolism and hypertensive disorders in pregnant women with sickle cell disease, suggesting need for targeted interventions.
Key Points
Pregnant women with sickle cell disease have a significantly higher risk of venous thromboembolism and hypertensive disorders.
The meta-analysis included 38,386 pregnancies in women with sickle cell disease and over 19 million in those without, highlighting increased risks.
Systematic review of cohort and case control studies examined the incidence of various hypertensive disorders and venous thromboembolism in sickle cell disease.
These findings underline the importance of clinical trials, like those investigating aspirin and heparin, to improve pregnancy outcomes in sickle cell disease.