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December 8, 2025Blood

Matched unrelated vs. Haploidentical  donor for allogeneic stem cell transplantation in patients with acute leukemia with identical GvHD prophylaxis – a randomized prospective european trial.

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Authors

NKNicolaus KroegerJSJaime SanzARAlessandro Rambaldi

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Overview

Randomized trial shows similar relapse and non-relapse mortality rates in patients with acute leukemia using haploHCT and MUD, suggesting low toxicity and feasible outcomes.

Key Points

  • Transplant type did not significantly differ in relapse rates at 2 years, with haploHCT showing 28% and MUD showing 33%.
  • The median age of participants was 56 years, reflecting varied demographics in both haploHCT and MUD groups.
  • Analysis highlighted comparable rates of GvHD and overall survival between haploHCT and MUD, indicating a sound treatment strategy.
  • Study results call into question the necessity for further recruitment in favor of haploHCT, due to lack of superiority demonstrated.

Cite This Study

Kroeger et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfbfhttps://doi.org/10.1182/blood-2025-171
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Matched Unrelated vs Haploidentical Donor Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide2025 · 7 citations
  2. 2T cell replete haploidentical transplantation compared to mismatched unrelated allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT2025
  3. 3Better outcomes with haploidentical than matched sibling donors for adult AML patients allo-transplanted in CR with detectable MRD: A study from the global committee and the ALWP of the EBMT.2025 · 1 citations
  4. 4Outcomes of HLA-matched unrelated versus haploidentical hematopoietic cell transplantation in acute leukemia: A multicenter observational study in Brazil facilitated by the CIBMTR2025
  5. 5Similar Outcome With Haploidentical, Matched Sibling, or Matched Unrelated Donor Hematopoietic Cell Transplantation for Adult Patients With Adverse‐Risk <i>TP53</i>‐Mutated Acute Myeloid Leukemia in First Remission: A Comparative Study From the Global Committee and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation2025 · 1 citations