Outcomes of HLA-matched unrelated versus haploidentical hematopoietic cell transplantation in acute leukemia: A multicenter observational study in Brazil facilitated by the CIBMTR
Observational study examines treatment outcomes of hematopoietic cell transplantation in acute leukemia patients, indicating comparable results between donor types.
Key Points
Overall survival and relapse rates were not significantly different between donor types in acute leukemia patients.
In a cohort of 501 patients, the relapse incidence was 20% for haploidentical and 14% for HLA-matched donors.
Multicenter observational study conducted across 21 centers in Brazil from 2018 to 2021 gathered extensive patient data.
Findings support both haploidentical and HLA-matched transplants as viable options for patients without matched siblings.