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December 8, 2025BloodOpen Access

Better outcomes with haploidentical than matched sibling donors for adult AML patients allo-transplanted in CR with detectable MRD: A study from the global committee and the ALWP of the EBMT.

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Authors

MLMyriam LabopinIYIbrahim Yakoub‐AghaMSMatthias Stelljes

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Overview

Observational analysis shows haploidentical transplant had better long-term survival in AML patients, indicating a stronger graft-versus-leukemia effect.

Key Points

  • Haploidentical transplant was associated with improved LFS and GRFS in patients with AML in MRD positive complete remission, suggesting a preferred donor option.
  • Multivariable analysis revealed a hazard ratio of 1.55 for disease relapse risk with matched sibling donors compared to haploidentical transplants, highlighting significant differences.
  • Data from 3385 adult AML patients receiving first allogeneic hematopoietic cell transplants and their outcomes were analyzed across multiple centers.
  • Older patient age showed a hazard ratio of 1.23 for increased non-relapse mortality, underscoring the need for careful donor selection.

Cite This Study

Labopin et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d758https://doi.org/10.1182/blood-2025-1059
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Matched sibling donors still provide superior survival outcomes in older patients with AML in second complete remission. a study from the global committee and the acute leukemia working party of the european society for blood and marrow transplantation2025
  2. 2Similar Outcome With Haploidentical, Matched Sibling, or Matched Unrelated Donor Hematopoietic Cell Transplantation for Adult Patients With Adverse‐Risk <i>TP53</i>‐Mutated Acute Myeloid Leukemia in First Remission: A Comparative Study From the Global Committee and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation2025 · 1 citations
  3. 3T cell replete haploidentical transplantation compared to mismatched unrelated allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT2025
  4. 4Comparable outcomes of haploidentical, sibling, and unrelated donor transplantation for adult T-ALL in second remission: a study from the global committee and ALWP of the EBMT2025
  5. 5Matched unrelated vs. Haploidentical  donor for allogeneic stem cell transplantation in patients with acute leukemia with identical GvHD prophylaxis – a randomized prospective european trial.2025 · 2 citations