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December 8, 2025BloodOpen Access

T cell replete haploidentical transplantation compared to mismatched unrelated allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT

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Authors

YKYener KoçJPJiří PavlůSSSimona Sica

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Overview

Retrospective analysis shows comparable outcomes between haploidentical and mismatched unrelated transplants in patients with secondary acute myeloid leukemia, highlighting neutrophil recovery.

Key Points

  • To compare outcomes of haploidentical and mismatched unrelated donor transplants in patients with secondary acute myeloid leukemia in first complete remission.
  • Retrospective comparison of haploidentical and mismatched unrelated donor HSCT from 2010 to 2022
  • Outcomes measured using multivariate Cox regression model
  • Analyzed factors like conditioning, GVHD incidence, and overall survival
  • Haploidentical transplantation showed faster neutrophil recovery compared to mismatched unrelated transplantation
  • Cumulative incidence of graft-versus-host disease was similar between the groups
  • Overall survival rates were comparable between haploidentical and mismatched unrelated transplant groups

Cite This Study

Koç et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cffchttps://doi.org/10.1182/blood-2025-114
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