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December 2, 2025Frontiers in ImmunologyOpen Access

Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC

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Authors

CMCarlos Martín‐RodríguezFPFelipe Peña-MuñózSFSara Fernández‐Luis

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Overview

Analysis demonstrates improved survival in younger donors for acute myeloid leukemia, suggesting prioritization of younger grafts in haplo-HCT.

Key Points

  • Younger donors reduced non-relapse mortality, enhancing overall survival for patients with acute myeloid leukemia.
  • Older donor age adversely affected overall survival, with high-risk AML associated with poorer outcomes in the cohort.
  • Assessment using multivariate analysis confirmed the significance of donor and recipient factors on transplant results.
  • Study findings support prioritizing younger donors to optimize hematopoietic cell transplantation outcomes.

Cite This Study

Martín‐Rodríguez et al. (2025) studied this question.

synapsesocial.com/papers/692e3d706c9b3ab28c186e67https://doi.org/10.3389/fimmu.2025.1700463
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