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July 31, 2025

Gentamicin alleviates intestinal graft-versus-host disease by modulating butyrate-associated gut microbiota

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Authors

LSLinlin ShaoYZYe ZhangYHYuefen Hu

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Overview

Mouse model demonstrated gentamicin reduces intestinal GVHD severity while butyrate worsens its effects, indicating complex interactions.

Key Points

  • Gentamicin significantly lessens mortality and GVHD scores in allo-HSCT mice.
  • Alterations in gut microbiota composition are noted with gentamicin treatment, lowering Clostridium levels.
  • Sodium butyrate caused increased mortality and exacerbated intestinal GVHD, linked to goblet cell apoptosis.
  • Timing of butyrate supplementation post-gentamicin illustrates a dual effect on GVHD outcomes.

Cite This Study

Shao et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf7e7https://doi.org/10.21203/rs.3.rs-7181845/v1
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