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December 8, 2025Blood

Somatic mutations in cancer-related genes in chronic myeloid leukemia patients receiving asciminib

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Authors

EKElena KuzminaOSOleg ShukhovATAnna Turkina

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Overview

Observational analysis shows somatic mutations lower cumulative incidence of treatment responses in chronic myeloid leukemia patients, indicating challenges with asciminib efficacy.

Key Points

  • Somatic mutations negatively impact treatment outcomes in chronic myeloid leukemia patients.
  • Forty percent of patients exhibited DNMT3A mutations alongside a significant presence of RUNX1 mutations.
  • Analysis through survival analysis revealed lower response rates to treatment in patients with somatic mutations.
  • The study highlights the need for further exploration into how these mutations affect therapy effectiveness in CML.

Cite This Study

Kuzmina et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd6dhttps://doi.org/10.1182/blood-2025-2000
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic evolution in CML patients from diagnosis to TKI failure: An analysis of 121 paired diagnosis and treatment failure samples2025
  2. 2Somatic mutations at diagnosis in patients with chronic Phase CML receiving frontline imatinib are associated with a higher rate of treatment failure: First analysis from the international CML foundation (iCMLf) genomics alliance on the harmony platform2025 · 1 citations
  3. 3Beyond survival in chronic myeloid leukemia: A systematic review of secondary malignancies in the era of tyrosine kinase inhibitors2025
  4. 4ASXL1 and NOTCH1 mutations independently predict TKI treatment failure in chronic myeloid leukemia2025
  5. 5Prognostic impact of ASXL1 somatic mutation on patients with chronic myeloid leukemia: A systemic review and meta-analysis.2026