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December 8, 2025BloodOpen Access

Genetic evolution in CML patients from diagnosis to TKI failure: An analysis of 121 paired diagnosis and treatment failure samples

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Authors

MMMing-Chun MaCCChiu‐Chen ChenHCHung Chang

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Overview

Analysis reveals significant mutations during treatment failure in chronic myeloid leukemia, indicating challenges in therapy response.

Key Points

  • TKI failure is linked with complex clonal evolution, including stable clones and emerging mutations.
  • Somatic mutations were analyzed using next-generation sequencing in 121 CML patients from diagnosis to failure.
  • Notable mutations in transcription factors correlate with worsened overall and progression-free survival outcomes.
  • Understanding the role of epigenetic regulators and tumor suppressor mutations could enhance treatment strategies.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3eehttps://doi.org/10.1182/blood-2025-5555
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ASXL1 and NOTCH1 mutations independently predict TKI treatment failure in chronic myeloid leukemia2025
  2. 2Somatic mutations at diagnosis in patients with chronic Phase CML receiving frontline imatinib are associated with a higher rate of treatment failure: First analysis from the international CML foundation (iCMLf) genomics alliance on the harmony platform2025
  3. 3Dynamic mutational evolution and transcriptomic remodeling on 3rd-generation TKI therapy in TKI-resistant patients with chronic myeloid leukemia2025
  4. 4Somatic mutations in cancer-related genes in chronic myeloid leukemia patients receiving asciminib2025
  5. 5Genomic profiling in CLL patients after BTK inhibitor progression identifies enrichment of mutations in MAPK pathway and epigenetic regulators2025