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December 8, 2025BloodOpen Access

ASXL1 and NOTCH1 mutations independently predict TKI treatment failure in chronic myeloid leukemia

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Authors

TZTian ZengXYXiudi Yang

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Overview

Retrospective analysis reveals ASXL1 and NOTCH1 mutations correlate with TKI treatment failure in chronic myeloid leukemia patients, suggesting additional genomic risk factors.

Key Points

  • Chronic myeloid leukemia treatment outcomes are influenced by ASXL1 and NOTCH1 mutations, leading to TKI failure.
  • The study highlights significant associations between higher mutational burdens and older age as well as treatment resistance.
  • Assessment using next-generation sequencing analyzed mutations in 94 CML patients, revealing insights into TKI resistance.
  • Potential genomic alterations, such as transcription factors and histone methylation, may play critical roles in therapeutic response.

Cite This Study

Zeng et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e427https://doi.org/10.1182/blood-2025-5551
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