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December 8, 2025BloodOpen Access

Safety and feasibility of outpatient myeloablative total marrow and lymphoid Irradiation–based allogeneic transplantation in adults with high-risk acute lymphoblastic leukemia

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Authors

MCMiguel CamposLTLuz TarinALAndrés Gómez‐De León

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Overview

Phase 2 trial shows TMLI-based allogeneic transplantation is feasible in young adults with acute lymphoblastic leukemia, indicating reduced toxicity.

Key Points

  • Graft-versus-host disease occurred in 57.1% of recipients, with no early deaths reported within 60 days post-transplant.
  • The median follow-up duration was 11 months, with overall survival at 81.3% and relapse-free survival at 80%.
  • Per protocol, the conditioning regimen included cyclophosphamide and fludarabine followed by TMLI for acute lymphoblastic leukemia.
  • The study supports TMLI as a viable outpatient treatment option for acute lymphoblastic leukemia, warranting further research.

Cite This Study

Campos et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236dbbahttps://doi.org/10.1182/blood-2025-6000
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety of myeloablative total marrow and lymphoid irradiation versus chemotherapy-based conditioning in adults with high-risk acute lymphoblastic leukemia in a limited resources setting2025
  2. 2Total marrow and lymphoid irradiation (2000 cGy) together with cyclophosphamide and etoposide prior to allogeneic hematopoietic cell transplantation is an effective regimen for Relapsed/Refractory leukemia, with low non-relapse mortality2025
  3. 3Total marrow and lymphoid irradiation (TMLI) with fludarabine-melphalan (FM) conditioning for matched donor hematopoietic cell transplant (HCT) in older patients with Relapsed/Refractory (R/R) disease2025
  4. 4Total marrow irradiation based conditioning for allogeneic hematopoietic stem cell transplantation in elderly or frail patients with hematological malignancies: A single center analysis2025
  5. 5Outcome of allogeneic hematopoietic cell transplantation in adult acute lymphoblastic leukemia patients who underwent myeloablative TBI-free conditioning regimen2025 · 1 citations