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December 8, 2025Blood

Safety of myeloablative total marrow and lymphoid irradiation versus chemotherapy-based conditioning in adults with high-risk acute lymphoblastic leukemia in a limited resources setting

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Authors

MCMiguel CamposJHJosue A. Hernandez-BenitezPCPerla R. Colunga‐Pedraza

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Overview

Retrospective study shows total marrow irradiation has similar safety and GVHD rates in adults with acute lymphoblastic leukemia, suggesting potential as a standard conditioning approach.

Key Points

  • The safety profile of total marrow irradiation is comparable to chemotherapy-based conditioning in acute lymphoblastic leukemia.
  • Acute graft-versus-host disease occurred in 45.5% of patients receiving total marrow irradiation, with no significant difference from controls.
  • Retrospective multicenter analysis evaluated outcomes and adverse events among patients receiving different conditioning regimens.
  • Total body irradiation remains a standard treatment, yet potential toxicity highlights ongoing need for effective alternatives.

Cite This Study

Campos et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236dbabhttps://doi.org/10.1182/blood-2025-5998
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety and feasibility of outpatient myeloablative total marrow and lymphoid Irradiation–based allogeneic transplantation in adults with high-risk acute lymphoblastic leukemia2025
  2. 2Total marrow and lymphoid irradiation (TMLI) with fludarabine-melphalan (FM) conditioning for matched donor hematopoietic cell transplant (HCT) in older patients with Relapsed/Refractory (R/R) disease2025
  3. 3Total marrow and lymphoid irradiation (2000 cGy) together with cyclophosphamide and etoposide prior to allogeneic hematopoietic cell transplantation is an effective regimen for Relapsed/Refractory leukemia, with low non-relapse mortality2025
  4. 4Total marrow irradiation based conditioning for allogeneic hematopoietic stem cell transplantation in elderly or frail patients with hematological malignancies: A single center analysis2025
  5. 5First-in-human phase I trial combining radiopharmaceutical therapy (RPT) using a 90y-anti-CD25 monoclonal antibody (Mab) with total marrow and lymphoid irradiation (TMLI) in relapsed or refractory (R/R) acute leukemia2025