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September 10, 2025Leukemia & lymphoma/Leukemia and lymphoma

Outcome of allogeneic hematopoietic cell transplantation in adult acute lymphoblastic leukemia patients who underwent myeloablative TBI-free conditioning regimen

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Authors

DADelaram AmiriMMMandana MirzaeiTBTanaz Bahri

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Overview

Retrospective analysis reveals improved overall survival and disease-free survival in adult ALL patients after TBI-free transplantation, indicating its potential as a viable alternative.

Key Points

  • Overall survival significantly improved from 38.3% to 48.1% in patients post-2010.
  • Disease-free survival also increased from 36.6% to 42.0% in the same time frame.
  • Relapse incidence decreased notably from 47.5% to 40.8% post-2010.
  • Non-relapse mortality remained stable during the period at around 28.5% to 24.9%.

Cite This Study

Amiri et al. (2025) studied this question.

synapsesocial.com/papers/68c24317b210217d647a511bhttps://doi.org/10.1080/10428194.2025.2548968
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety and feasibility of outpatient myeloablative total marrow and lymphoid Irradiation–based allogeneic transplantation in adults with high-risk acute lymphoblastic leukemia2025
  2. 2Clinical efficacy of allogeneic hematopoietic stem cell transplantation in infant acute leukemia2025
  3. 3Salvage allogeneic hematopoietic stem cell transplantation conditioning regimens for relapsed/refractory acute leukemia: Efficacy of radiotherapy combined with CLAG vs FLAG2025
  4. 4Impact of conditioning regimen on outcomes of adolescents and young adults AML patients undergoing HCT in complete remission, with transplant conditioning intensity score of 3.5-4.0. a study from the acute leukemia working party of the european society for blood and marrow transplantation.2025 · 1 citations
  5. 5Thiotepa and busulfan combined with cyclophosphamide conditioning regimen plus maintenance therapy improved the disease-free survival of patients with relapsed/refractory haematologic malignancies after undergoing allogeneic transplantation2025