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December 8, 2025BloodOpen Access

Single-cell DNA sequencing uncovers synergistic co-mutations in multiple myeloma

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Authors

ELElizabeth LyubchenkoSFStephanie FernandesMKMarcella Kaddoura

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Overview

Single-cell DNA sequencing shows co-occurring mutations in multiple myeloma, indicating shared genomic mechanisms of resistance.

Key Points

  • Resistance-related mutations were identified through single-cell DNA sequencing in multiple myeloma tumor cells.
  • Notable mutations include TP53 and other alterations that suggest a selective growth advantage.
  • Genomic profiling targeting multiple variants was performed on 48 samples from myeloma patients.
  • Findings may guide future immunotherapy approaches for treating myeloma with co-mutated lesions.

Cite This Study

Lyubchenko et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db66https://doi.org/10.1182/blood-2025-2157
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  5. 5Multiomic evidence of coordinated complex rearrangements, enhancer hijacking, and epigenomic signatures in the first whole-chromosome-phased myeloma genomes2025