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December 8, 2025Blood

Targeted long-read sequencing with adaptive sampling in multiple myeloma: A pilot study toward a unified diagnostic platform

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Authors

BABeñat AricetaSVSaioa VicenteMCMarı́a José Calasanz

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Overview

Pilot study demonstrates comprehensive genomic profiling in multiple myeloma, suggesting precision oncology applications.

Key Points

  • Low-coverage whole-genome sequencing detected genetic alterations in all patients with multiple myeloma.
  • Genomic DNA from 17 MM patients was analyzed, revealing chromosomal abnormalities and structural variants.
  • Assessment using adaptive long-read sequencing on the PromethION platform provided detailed genomic insights.
  • Precision oncology may benefit from broad genomic coverage and unselected analysis of tumor genomes.

Cite This Study

Ariceta et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6e6https://doi.org/10.1182/blood-2025-6121
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